Sarah K. Zingales, Ph.D.
Associate Professor, Chemical and Environmental Sciences
Department of Science
Dr. Zingales is a teacher-scholar focused on Organic Chemistry. She teaches courses and runs an organic/medicinal chemistry research laboratory with a focus on design and synthesis of small molecules for a variety of research projects including anticancer therapeutics and developing novel umpulong Biginelli-like reactions. She is also active in Chemical Education studying how students learn organic chemistry.
Education
- B.S. Chemistry, 2005, Auburn University
- M.S. Organic Chemistry, 2010, Georgia State University
- Ph.D. Medicinal Chemistry, 2013, Georgia State University
Courses Taught
- General Chemistry
- Organic Chemistry
- Medicinal Chemistry
Selected Publications and Presentations
- East, A.; Polasek, C.G.; Miller, E.A.; Ranganathan, S.; Reda, I.D.; Patel, A.; Ahlers, C.D.; Zingales, S.K.; Karver, C.E. Expansion of the structure-activity relationship profile of triaminopyrimidines as inhibitors of caspase-1. Chemical Biology & Drug Design, 2024, 109, e70031. http://dx.doi.org/10.1111/cbdd.70031
- Wackerly, J.W.; Wentzel, M.T.; Zingales, S.K.Teaching Abductive Reasoning for Use as a Problem-Solving Tool in Organic Chemistry and Beyond. Frontiers in Education STEM Education: Organic Chemistry Research Into Practice, 2024, 9, 1412417. https://doi.org/10.3389/feduc.2024.1412417
- Grice, K.A.; Varsbergs, Z.M.; Zhang, Y.; Zingales, S.K.;Johnson, A.R.; Sommer, R.D.; Karver, C.E. Structural, Computational, Docking and Biological Studies of a Triaminopyrimidine Caspase-1 Inhibitor. Journal of Molecular Structure, 2024, 1318 (2) 139297. https://doi.org/10.1016/j.molstruc.2024.139297
- Moster, C.A.; Zingales, S.K.Use of specifications-based grading in an online, asynchronous graduate organic chemistry course. Frontiers in Education Sec. STEM Education: Organic Chemistry Research Into Practice, 2024, 9, 1379216. https://doi.org/10.3389/feduc.2024.1379216
- Smith, R.; Roberts, W.; Upenieks, M.; Gibson, M.Z.; Wentzel, M.T.; Grice, K.A.; Zingales, S.K.Synthesis and conformational analysis of N-BOC-protected-3,5-bis(arylidene)-4- piperidone EF-24 analogs as anti-cancer agents. Heterocyclic Communications Special Issue: Undergraduate Research in the Synthesis of Biologically Active Small Molecules and Their Applications, 2023, 29 (1), 20220162. https://doi.org/10.1515/hc-2022-0162
Awarded Grants
- American Chemical Society Petroleum Research Fund for Undergraduate Research (ACS-PRF UR), ACS, 2023-2026, “Investigating the Mechanism and Activity of T3P as a Dehydrating Reagent in Organic Synthesis” Sarah Zingales (PI), funded $70,000
- Organic Syntheses, Inc. Grant for Summer Research at a Principally Undergraduate Institution, 2022-2023, “A multi-PUI collaboration into developing an umpolung Biginelli-like reaction: investigating the role of the carbamate leaving group and nucleophile to synthesize novel oxazolinones” Sarah Zingales (PI), $16,000
Research Interests
- Medicinal Chemistry: synthesizing small libraries of compounds based on natural products and testing their medicinal properties (anti-cancer and anti-alzheimers)
- Organic Chemistry: developing umpluong Biginelli-like reactions to synthesize oxazinones and investigating the linear free energy relationships of bis-aldol condensations
- Chemical Education: assessing undergraduate curriculum and how students learn organic chemistry
Professional Affiliations
- American Chemical Society
