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Home / Academics / Academic Majors / Marine and Environmental Sciences / Marine and Environmental Sciences Faculty and Staff / Sarah K. Zingales

Sarah K. Zingales, Ph.D.

Associate Professor, Chemical and Environmental Sciences Department of Science

Sarah Zingales, Ph.D.Dr. Zingales is a teacher-scholar focused on Organic Chemistry. She teaches courses and runs an organic/medicinal chemistry research laboratory with a focus on design and synthesis of small molecules for a variety of research projects including anticancer therapeutics and developing novel umpulong Biginelli-like reactions. She is also active in Chemical Education studying how students learn organic chemistry.

Education

  • B.S. Chemistry, 2005, Auburn University
  • M.S. Organic Chemistry, 2010, Georgia State University
  • Ph.D. Medicinal Chemistry, 2013, Georgia State University

Courses Taught

  • General Chemistry
  • Organic Chemistry
  • Medicinal Chemistry

Selected Publications and Presentations

  • Wackerly, J.W.; Wentzel, M.T.; Zingales, S.K. Teaching Abductive Reasoning for Use as a Problem-Solving Tool in Organic Chemistry and Beyond. Frontiers in Education Sec. STEM Education: Organic Chemistry Research Into Practice, 2024, 9, 1412417. https://doi.org/10.3389/feduc.2024.1412417
  • Grice, K.A.; Varsbergs, Z.M.; Zhang, Y.; Zingales, S.K.; Johnson, A.R.; Sommer, R.D.; Karver, C.E. Structural, Computational, Docking and Biological Studies of a Triaminopyrimidine Caspase-1 Inhibitor. Journal of Molecular Structure, 2024, 1318 (2) 139297. https://doi.org/10.1016/j.molstruc.2024.139297
  • Moster, C.A.; Zingales, S.K. Use of specifications-based grading in an online, asynchronous graduate organic chemistry course. Frontiers in Education Sec. STEM Education: Organic Chemistry Research Into Practice, 2024, 9, 1379216. https://doi.org/10.3389/feduc.2024.1379216
  • Smith, R.; Roberts, W.; Upenieks, M.; Gibson, M.Z.; Wentzel, M.T.; Grice, K.A.; Zingales, S.K. Synthesis and conformational analysis of N-BOC-protected-3,5-bis(arylidene)-4- piperidone EF-24 analogs as anti-cancer agents. Heterocyclic Communications Special Issue: Undergraduate Research in the Synthesis of Biologically Active Small Molecules and Their Applications, 2023, 29 (1), 20220162. https://doi.org/10.1515/hc-2022-0162
  • Ferguson, J.; Zingales, S.K. Chapter 9 – AI in Microfabrication Technology. In A Handbook of Artificial Intelligence in Drug Delivery; Philip, A., Shahiwala, A., Rashid, M., Faiyazuddin, Md., Eds.; Academic Press, 2023; pp 213–239. https://doi.org/10.1016/B978-0-323-89925-3.00008-3
  • Dean, R.; Miller, C.N.; Zingales, S.K.; Padgett, C.W. 3-(4-Iodophenyl)-2,3-dihydro-1H-benzo[f]chro-men-1-one. IUCrData 2020, 5, x20011. DOI:10.1107/S2414314620001108
  • Gremillion, S.; Zingales, S. Baird, W.; Durden, A.; Hunter, N.; Durden, A. Hessinger, S. The Current State of High School Female and Minority Self-efficacy and Interest in STEM in Chatham County, Georgia. Georgia Educational Researcher 2019, 16 (2), Article 1, 1-22. https://digitalcommons.georgiasouthern.edu/gerjournal/vol16/iss2/1

Awarded Grants

  • American Chemical Society Petroleum Research Fund for Undergraduate Research (ACS-PRF UR), ACS, 2023-2026, “Investigating the Mechanism and Activity of T3P as a Dehydrating Reagent in Organic Synthesis” Sarah Zingales (PI), funded $70,000
  • Organic Syntheses, Inc. Grant for Summer Research at a Principally Undergraduate Institution, 2022-2023, “A multi-PUI collaboration into developing an umpolung Biginelli-like reaction: investigating the role of the carbamate leaving group and nucleophile to synthesize novel oxazolinones” Sarah Zingales (PI), $16,000

Research Interests

  • Medicinal Chemistry: synthesizing small libraries of compounds based on natural products and testing their medicinal properties (anti-cancer and anti-alzheimers)
  • Organic Chemistry: developing umpluong Biginelli-like reactions to synthesize oxazinones and investigating the linear free energy relationships of bis-aldol condensations
  • Chemical Education: assessing undergraduate curriculum and how students learn organic chemistry

Professional Affiliations

  • American Chemical Society
Google Scholar Profile
Website

Contact Information

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